Graves disease is a type II immune response that targets thyroid stimulating hormone (TSH) receptors on the thyroid. Even though the excessive T3 and T4 in the blood stream downregulate the production of TSH, antibodies continue to stimulate the receptors causing an increase in T3 and T4 production. Graves disease is essentially a form of hyperthyroidism and, as such, would show hypertrophic epithelial cells and profoundly scalloped colloid within the follicles.