Copyright © 2004-2013 Duke University School of Medicine
|
Diseases of the Skin |
||
Gartner & Hiatt Atlas (5th ed): |
|
|
Text (Junqueira's 12th ed): | Ch 18, Skin, pp. 316-330 | |
Text (Robbins 8th ed): |
|
|
Skin Pathology Cases UMich Slide 24 [WebScope][ImageScope] Skin and Subcutis: Chronic Ulcer This slide represents a non-healing scalp lesion from a 43-year-old man.
UMich Slide 25 [WebScope][ImageScope] Skin: Scar This 27-year-old patient had a pigmented skin lesion excised which turned out to be a melanoma. 6 weeks later, another biopsy was performed at the same site to confirm complete removal of the neoplasm and absence of recurrence. As shown in the specimen, there is no remaining neoplasm, but scar tissue from initial biopsy procedure is evident.
UMich Slide 178 [WebScope] [ImageScope] History: A 35-year-old man was clearing a path in the woods. When he returned home, he noticed an intensely pruritic linear vesicular eruption on his extensor forearms. A skin biopsy was taken. Histologic features: There is pronounced spongiosis (intercellular edema) within the epidermis resulting in intraepidermal vesicles. Exocytosis of lymphocytes (lymphocytic spongiosis) may be seen in the epidermis. There is a superficial perivascular lymphocytic infiltrate.
UMich Slide 198 [WebScope] [ImageScope] History: A 45-year-old woman complained of a scaly rash present for many years. On exam were multiple, well demarcated erythematous papulosquamous plaques on the elbows, arms and knees. Erythema and white scale were also present on her scalp. A skin biopsy was taken. Histologic features: There is near confluent parakeratosis, hypogranulosis, and regular psoriasiform hyperplasia of the epidermis with slight clubbing of the rete pegs. Neutrophilic fragments can be identified in the stratum corneum and in the upper epidermis. Dilated and tortuous blood vessels are seen in the dermal papillary tips.
UMich Slide 39 [WebScope] [ImageScope] History: A 12-year-old boy complained of a slowly growing papule with a thickened surface on his finger. The lesion was biopsied. Histologic features: There is hyperkeratosis, papillomatosus, and acanthosis. Within the granular cell layer, diagnostic koilocytes containing "raisin-like" nuclei are seen. Intracytoplasmic viral inclusions may also occasionally be seen.
UMich Slide 128 [WebScope] [ImageScope] History: A 65-year-old man complained of a slowly growing lesion on his nose. On exam, an ulcerated pearly nodule with dilated blood vessels was noted. The lesion was surgically excised and submitted to pathology for analysis. Histologic features: There are multiple islands of neoplasia extending into the dermis demonstrating peripheral palisading and stromal retraction artifact. Connection of the neoplastic islands to the stratum basale of the epidermis is often identified.
UMich Slide 123 [WebScope] [ImageScope] History: A 30-year-old woman presented with a symmetric, uniformly pigmented, dome-shaped papule on her face. She requests its removal. Histologic features: There is a dome-shaped, symmetric papule with multiple nests of bland nevus cells at the dermo-epidermal junction and in the dermis. Nevus cells are slightly larger in the superficial portion of the lesion and become smaller or "mature" with descent into the dermis. There is no cytologic atypia.
Slide 129 [WebScope] [ImageScope] History: A 24-year-old medical student, who used to work summers as a lifeguard, complained of a changing mole on her leg. It had begun to itch and recently darkened in color. The lesion was biopsied. Histologic features: There are cytologically atypical melanocytes at the dermo-epidermal junction and in the dermis. Nuclei are large with occasionally prominent nucleoli. Rare mitotic figures are present. The lesion is asymmetric and poorly circumscribed.
|
||